Our analytical services characterize cells and tissues so that you can rest assured they meet your research requirements. We execute your experimental design according to your specifications.

Our analytical capabilities complement one another to provide you a full understanding of protein expression and drug target localization.

 

IHC and Histology

ABS can prepare fixed or frozen slides and conduct specially tailored immunohistochemistry (IHC) services for all tissues we offer. We can also use samples provided by you.

Our team can process tissues and cells into paraffin blocks, embed samples using OCT, and localize proteins in cells using histogels. We’re also experienced with preparing slides, H&E staining, and special stains, as well as gathering morphological data to help validate your biochemical or genomic data sets.

Additional IHC (single and multiple labels) capabilities include:

  • Assay development for your antibody, as well as a full range of tissues with appropriate IHC and western controls
  • Drug target and biomarker distribution studies in animal and normal and diseased human tissues
  • Antibody specificity studies (FDA panels available)
  • Image analysis to provide quantification and statistical data for your special project needs

Flow Cytometry

Using cell or blood samples provided by your laboratories, from our tissue culture facility or from our biospecimen network, our flow cytometry services include:

  • Phenotypic analysis of cells, tissues, and blood using up to eight-color antibody panels
  • Separation and enrichment of cell populations using magnetic bead technologies
  • GLP and 21 CFR Part 11-compliant studies

Gene Expression

Central to the discovery of biomarkers for precision medicine and for the development of selective therapeutics, our fully customizable gene and expression analyses include:

  • RNA and DNA purification using automated or manual methods
  • cDNA preparation
  • PCR and qPCR
  • SNP analysis
  • RT-qPCR

Western Analysis

Essential for detecting and quantifying proteins in biological samples, western analysis at ABS uses both colorimetric and fluorescence methods in our services:

  • Detection of protein of interest
  • Monitoring of protein purification
  • Measurement of the purity of cell fractions using specific markers
  • Protein localization in tissues and cell fractions
  • Protein quantification in extracts
  • Antibody characterization and specificity analysis

charlie-saller

 

Reviewed by Charles F. Saller, Ph.D. 

Prior to founding ABS, Dr. Saller led the biochemical team at what is now AstraZeneca that worked on the discovery of Seroquel®, one of the most successful drugs of all time both in respect to therapeutic efficacy for psychiatric disorders and market value. Dr. Saller is a serial entrepreneur, having founded Saller Rental Properties in the 1980s, which provided the capital for founding ABS in January 1990. He continues to lead ABS operations and direct its strategy. Dr. Saller has also served as the Principal Investigator or has administered more than $5 million in government grants and contracts as a founder of one other bioscience company and as advisor to others.