Day One is a bit of an over-simplification. As I remember it nearly 30 years ago, there wasn’t really a clear day one. The transition to starting ABS was more gradual. While working on Seroquel® at ICI Americas, I leased a small laboratory at the Philadelphia College of Pharmacy to use at night to make membrane preparations. I and two technicians would drive up to Philadelphia after working all day and then sacrifice 100 rats that were delivered that day and begin homogenizing and centrifuging rat brain membrane preparations well into the night. I had purchased one centrifuge and there were various other centrifuges on two separate floors that we could access by running up and down flights of stairs so that the membranes were quickly processed. This was a low-cost test of the feasibility of the idea for the business and good exercise.